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**Tom Kindlon** @tomkindlon@disabled.social · 2 j

2 j

Tom Kindlon @tomkindlon@disabled.social

Mitigating fatigue in long COVID patients with MYPplus: a clinical observation

https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-025-10984-6

Screenshot is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

BMC Infectious Diseases
Mitigating fatigue in long COVID patients with MYPplus: a clinical observation — Choi et al.
"This observational study aimed to evaluate the efficacy of MYPplus, an herbal formulation composed of Astragali Radix, Salviae Radix, and Aquilariae Lignum, in alleviating fatigue and brain fog in patients with Long COVID."

**Tom Kindlon** @tomkindlon@disabled.social · 2 j

2 j

Tom Kindlon @tomkindlon@disabled.social

Risk of post-acute symptoms among adults: A comparison study of severe COVID-19, pneumonia, and influenza

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0322020

Screenshot is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

PLOS ONE
Risk of post-acute symptoms among adults: A comparison study of severe COVID-19, pneumonia, and influenza — Caroline M. Schaefer et al.
"Those with influenza were less likely than those with COVID-19 to experience post-acute symptoms while those with pneumonia were more likely to have post-acute illness than those with COVID-19."

**Tom Kindlon** @tomkindlon@disabled.social · 2 j

2 j

Tom Kindlon @tomkindlon@disabled.social

Trajectories of persisting Covid- 19 symptoms up to 24 months after acute infection: findings from the Predi-Covid cohort study

https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-025-11023-0

Screenshot is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

BMC Infectious Diseases
Trajectories of persisting Covid- 19 symptoms up to 24 months after acute infection: findings from the Predi-Covid cohort study — Fischer et al.
"We identified 2 total symptom score trajectories: T1 “Mild symptoms, fast resolution” (N = 376; 67.7%), and T2 “Elevated and persisting symptoms” (N = 179; 32.3%)."

**Tom Kindlon** @tomkindlon@disabled.social · 2 j

2 j

Tom Kindlon @tomkindlon@disabled.social

From Sweden:

Complement activation was not increased in patients with post-acute sequelae after mild SARS-CoV-2 infection: A prospective cohort study

https://www.medrxiv.org/content/10.1101/2025.04.26.25326246v1

Screenshot is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 #CovidIsNotOver
@auscovid19 #auscovid19

Preprint: MedRxiv
Complement activation was not increased in patients with post-acute sequelae after mild SARS-CoV-2 infection: A prospective cohort study — Madlene Holmqvist et al.
"We analyzed the complement activation markers C3bc, C3bBbP and TCC in 48 PASC patients." "Although the patients with a mild SARS-CoV-2 infection had a trend towards more severe PASC, we could not find any significant differences in complement activation markers between these patients and controls."

**Tom Kindlon** @tomkindlon@disabled.social · 3 j

3 j

Tom Kindlon @tomkindlon@disabled.social

From Brazil:

Acute and chronic post-COVID-19 conditions: A study of genetic integrity and clinical markers

https://www.sciencedirect.com/science/article/abs/pii/S1383571825000294

Screenshot is from the latest Science for ME weekly update

Mutation Research - Genetic Toxicology and Environmental Mutagenesis
Acute and chronic post-COVID-19 conditions: A study of genetic integrity and clinical markers — Martins et al.
"results suggest that genetic instability, as assessed by the comet assay, may not account for the clinical differences observed in post-COVID-19 syndrome" "The biochemical parameters analyzed in our study revealed important differences between the acute and chronic post-COVID groups, as well as between genders"

**Tom Kindlon** @tomkindlon@disabled.social · 3 j

3 j

Tom Kindlon @tomkindlon@disabled.social

From Germany:

Hyper-reactivity of CD8+ T cells and high expression of IL-3 correlates with occurrence and severity of Long-COVID

https://www.sciencedirect.com/science/article/pii/S1521661625000774

Screenshot is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

Clinical Immunology
Hyper-reactivity of CD8+ T cells and high expression of IL-3 correlates with occurrence and severity of Long-COVID — Renner et al.
"Long-COVID patients showed clear signs of T cell hyper-activation predominantly in the CD8+ T cell subset with a 4-fold higher expression of CD25 and 2-fold more effector-memory T cells. Following polyclonal T cell stimulation, we found a 2-fold stronger upregulation of CD25 and a 7-fold higher release of IL-3 in Long-COVID."

**Tom Kindlon** @tomkindlon@disabled.social · 4 j

4 j

Tom Kindlon @tomkindlon@disabled.social

(US)
#MillionsMissing 2025: Sending Out An SOS

https://www.meaction.net/2025/04/02/millionsmissing-2025-sending-out-an-sos/

Screenshot from the AMMES May email newsletter

@mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers

#MillionsMissing 2025: Sending Out An SOS
This #MillionsMissing, we are launching a campaign that is largely focused on the seismic cuts being made to research funding, healthcare, and disability services in the U.S.
We know that the state of U.S. research institutions will have a massive impact on whether we are able to advance research for myalgic encephalomyelitis (ME) and Long COVID over the next decade. This will impact everyone globally. We encourage you to join in the fight as we send an SOS to our governments to Save our Support Systems. Save our Science. Save Our Society!
Read more here>>

**Tom Kindlon** @tomkindlon@disabled.social · 5 j

5 j

Tom Kindlon @tomkindlon@disabled.social

Important new research from the Netherlands:

Skeletal muscle properties in long COVID and ME/CFS differ from those induced by bed rest

https://www.medrxiv.org/content/10.1101/2025.05.02.25326885v1

@mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers @covid19 #Coronavirus
#COVID19 #COVID #COVID_19 #COVIDー19 #SARSCoV2 @novid@chirp.social #novid @novid@a.gup.pe #CovidIsNotOver
@auscovid19 #auscovid19

Abstract
Patients with long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) suffer from a reduced exercise capacity, skeletal muscle abnormalities and post-exertional malaise (PEM), where symptoms worsen with cognitive or physical exertion. PEM often results in avoidance of physical activity, resulting in a lower aerobic fitness, which may contribute to skeletal muscle abnormalities. Here, we compared whole-body exercise responses and skeletal muscle adaptations after strict 60-day bed rest in healthy people with those in patients with long COVID and ME/CFS, and healthy age- and sex-matched controls. Bed rest altered the respiratory and cardiovascular responses to (sub)maximal exercise, while patients exhibited respiratory alterations only at submaximal exercise. Bed rest caused muscle atrophy, and the reduced oxidative phosphorylation related to reductions in maximal oxygen uptake. Patients with long COVID and ME/CFS did not have muscle atrophy, but had less capillaries and a more glycolytic fibers, none of which were associated with maximal oxygen uptake. While the whole-body aerobic capacity is similar following bed rest compared to patients, the skeletal muscle characteristics differed, suggesting that physical inactivity alone does not explain the lower exercise capacity in long COVID and ME/CFS

**Tom Kindlon** @tomkindlon@disabled.social · 6 j

6 j

Tom Kindlon @tomkindlon@disabled.social

Documentary: Doctors as Patients

https://youtu.be/J0ywwLIfH_w?si=hZv0mzlGtnLzpwim

Screenshot is from the latest Science for ME weekly update

Documentary Doctors as Patients
A moving, honest and thought provoking documentary interviewing five medical doctors with post-acute infection-associated syndromes like ME, Long Covid and chronic Lyme. They talk about their experiences, what they were taught about these illnesses as students and what they have learned as patients. Directed by Anil van der Zee. The documentary is in Dutch and has English subtitles.
Documentary l Thread

**Tom Kindlon** @tomkindlon@disabled.social · 4 mai

4 mai

Tom Kindlon @tomkindlon@disabled.social

New from Systrom team (US):

Exercise Pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID: Commonalities Detected by Invasive Cardiopulmonary Exercise Testing

https://www.atsjournals.org/doi/abs/10.1164/ajrccm.2025.211.Abstracts.A7881

@mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME #LongCovid @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

**Tom Kindlon** @tomkindlon@disabled.social · 3 mai

3 mai

Tom Kindlon @tomkindlon@disabled.social

"Therapist Perspective: Dan Wyke"

https://chroniclivingtherapy.com/dan-wyke-interview/

Comment: I liked this. I was going to share extracts but I think it's all good.

@mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC
@chronicillness
@spoonies
#counselling

Dan Wyke - a therapist's perspective

Dan Wyke (a person-centred counsellor from the South of England) reflects on his experiences as a therapist and person with MECFS.

He shares ideas and suggestions for both people with #MECFS and also therapists who work with them.

Amongst other things, I asked Dan 'what sort of things can you ask a therapist at an introductory meeting to reassure yourself about their level of understanding?'

read the interview with Dan Wyke

**Tom Kindlon** @tomkindlon@disabled.social · 3 mai

3 mai

Tom Kindlon @tomkindlon@disabled.social

David Tuller's video interview with Andrew Ewing & David Joffe on Just-Published “Global Expert Consensus” on Long Covid, plus extract from associated press release

https://virology.ws/2025/05/02/trial-by-error-andrew-ewing-david-joffe-on-just-published-global-expert-consensus-on-long-covid/

Trial By Error: Andrew Ewing & David Joffe on Just-Published “Global Expert Consensus” on Long Covid
1 Comment / By David Tuller / 2 May 2025

By David Tuller, DrPH

*This is a crowdfunding period at University of California, Berkeley. If you appreciate my work and would like to make a donation (tax-deductible to US taxpayers) to the university in support of my position, here’s the link: https://crowdfund.berkeley.edu/project/46120

Last week, the journal Annals of Clinical Microbiology and Antimicrobials published the results of a major effort to collate international expertise on Long Covid. The article–“Long COVID clinical evaluation, research and impact on society: a global expert consensus”—was produced under the auspices of the Long COVID Advisory Group of the World Health Network, a global collaborative.

Earlier today, I spoke with Andrew Ewing, the document’s lead and corresponding author and a professor of chemistry and microbiology at the University of Gothenburg, Sweden, and David Joffe, a co-author and a respiratory and sleep physician in Sydney, Australia. Below, I have posted information from the World Health Network’s press release, which calls the situation “a wake-up call for governments and health systems,” followed by the interview.

**Tom Kindlon** @tomkindlon@disabled.social · 3 mai

3 mai

Tom Kindlon @tomkindlon@disabled.social

"Long COVID clinical evaluation, research and impact on society: a global expert consensus"

https://ann-clinmicrob.biomedcentral.com/articles/10.1186/s12941-025-00793-9

Screenshot is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

Annals of Clinical Microbiology and Antimicrobials
Long COVID clinical evaluation, research and impact on society: a global expert consensus — Ewing et al.
"A 3‑round modified Delphi consensus methodology was distributed internationally to 179 healthcare professionals, researchers, and persons with lived experience of Long COVID in 28 countries." "This work forms initial guidance to address the spectrum of Long COVID as a disease and reinforces the need for translational research and large‑scale treatment trials for treatment protocols."

**Tom Kindlon** @tomkindlon@disabled.social · 3 mai

3 mai

Tom Kindlon @tomkindlon@disabled.social

Global prevalence of long COVID and its most common symptoms among healthcare workers: a systematic review and meta-analysis

https://bmjpublichealth.bmj.com/content/3/1/e000269

Screenshot is from the latest Science for ME weekly update

@longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC

BMJ Public Health
Global prevalence of long COVID and its most common symptoms among healthcare workers: a systematic review and meta-analysis — Amani Al-Oraibi et al.
"This review highlights the substantial burden of long COVID among HCWs worldwide. However, limitations in data quality and inconsistent definitions of long COVID impact the generalisability of these findings."

**Tom Kindlon** @tomkindlon@disabled.social · 3 mai

3 mai

Tom Kindlon @tomkindlon@disabled.social

The erasure of infection-associated chronic conditions: Critical interpretive synthesis of literature on healthcare for long COVID and related conditions in Brazil

https://www.tandfonline.com/doi/abs/10.1080/17441692.2025.2490720

Screenshot is from the latest Science for ME weekly update

Global Public Health
The erasure of infection-associated chronic conditions: Critical interpretive synthesis of literature on healthcare for long COVID and related conditions in Brazil — Flora Cornish et al.
"This article has identified processes of erasure of IACCs with damaging consequences for people living with long COVID and other IACCs, and exacerbation of health and social injustices."

**Tom Kindlon** @tomkindlon@disabled.social · 2 mai

2 mai

Tom Kindlon @tomkindlon@disabled.social

US (University of Iowa) research:

Relation of Immune Profile to Exercise-Induced Pain and Fatigue in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post-acute Sequelae of SARS-CoV-2 Infection

Paywall:
https://www.jpain.org/article/S1526-5900(25)00392-X/abstract

@mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers

**Tom Kindlon** @tomkindlon@disabled.social · 2 mai

2 mai

Tom Kindlon @tomkindlon@disabled.social

#MEAction’s Jaime Seltzer on Where We’ve Been, What We’ve Learned, and Where Things Are Now

https://virology.ws/2025/05/01/trial-by-error-meactions-jaime-seltzer-on-where-weve-been-what-weve-learned-and-where-things-are-now/

Video interview By David Tuller @david

@mecfs
#MyalgicEncephalomyelitis #ChronicFatigueSyndrome #MEcfs #CFS #PwME @longcovid
#LongCovid #PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers

Trial By Error: #MEAction’s Jaime Seltzer on Where We’ve Been, What We’ve Learned, and Where Things Are Now
1 Comment / By David Tuller / 1 May 2025
By David Tuller, DrPH

*This is a crowdfunding period at University of California, Berkeley. If you appreciate my work and would like to make a donation (tax-deductible to US taxpayers) to the university in support of my position, here’s the link: https://crowdfund.berkeley.edu/project/46120

It’s been five years, more or less, since the start of the coronavirus pandemic–and the subsequent wave of Long Covid. I spoke earlier today with Jaime Seltzer, #MEAction’s scientific director, about how early links were forged between advocates for people with ME and those experiencing what became known as Long Covid, what we’ve learned since, and where things are now. Seltzer was included on Time magazine’s list of the 100 “most influential people in health in 2024.”

**Tom Kindlon** @tomkindlon@disabled.social · 2 mai

**Tom Kindlon** @tomkindlon@disabled.social · 2 mai

2 mai

Tom Kindlon @tomkindlon@disabled.social

News Release

"Clinical trial underway for potential Long COVID treatment: Nova Southeastern University and the Schmidt Initiative for #LongCOVID will study the efficacy of a long-acting antibody for treating Long COVID"

https://www.eurekalert.org/news-releases/1082415

@longcovid
#PASC #PwLC #postcovid #postcovid19 #LC #Covidlonghaulers #PostCovidSyndrome #longhaulers #COVIDBrain #NeuroPASC